An old question that now has new answers: With habits and routines altered by quarantine and isolation, what is the best time for coffee? It all has to do with cortisol, the hormone that regulates sleep and wakefulness (unfairly ignored in a time with peaks of insomnia and difficulty sleeping). Cortisol acts on attention, focus and mental energy, metabolism, the reaction of the immune system and blood pressure: therefore, when you get up you are at the top of your function and having coffee at this time would lessen the influence of caffeine. The hormone has a sleep and wake cycle that reaches its maximum peak of function within 45 minutes of waking up and decreases throughout the day. Thus, if one gets up at 6.30 in the morning, the best time to have coffee would be at 9.30 because three hours after getting out of bed the cortisol is already at low levels (and the coffee brings a feeling of alertness for four hours, that is until 1.30). In conclusion: according to science, taking into account the time when most people get up, the ideal time to drink coffee is between 9.30 and 11.30. Enjoy!